Chelsea were beaten 2-1 by Wolves on Wednesday and manager Maurizio Sarri has responded by making significant changes.
Jorginho and David Luiz have been recalled to the team and come in from Andreas Christensen and Ruben Loftus-Cheek.
Cesc Fabregas drops to the bench which hands Mateo Kovacic a start in midfield.
In attack, Eden Hazard is the lone striker with Pedro and Willian in support.
For City, Pep Guardiola has made two changes.
Aymeric Laporte and Raheem Sterling replace Vincent Kompany and Gabriel Jesus.
Sergio Aguero misses out for the third successive game but Gabriel Jesus is dropped and Raheem Sterling returns to play up front.
Kick off at Stamford Bridge is 5.30pm.
Chelsea:Kepa, Alonso, Rudiger, Luiz, Azpilicueta, Jorginho, Kante, Kovacic, Pedro, Willian, Hazard.
Subs:Caballero, Fabregas, Barkley, Loftus-Cheek, Giroud, Christensen, Emerson.
Man City:Ederson, Walker, Stones, Laporte, Delph, Fernandinho, D. Silva, B. Silva, Mahrez, Sane, Sterling.
Subs:Muric, Danilo, Kompany, Gundogan, Otamendi, Jesus, Foden.